NM23 PROTEIN EXPRESSION IN RENAL-CELL TUMORS - THE ROLE OF THE CELL-TYPE

This study investigated nm23 protein expression in renal cell carcinom as to determine the relationship between nm23 protein expression and g rade, stage, prognosis and the cell type. 89 cases were examined by im munohistochemistry. Tubular epithelia were homogeneously stained. Cyto plasmic nm23 protein levels were reduced in renal cell carcinoma. nm23 protein levels persisted in oncocytomas, which are accepted to be ben ign. Cytoplasmic nm23 staining intensity did not show any correlation with stage and grade of tumor nor prognosis. Reduction in nm23 protein levels may have a role during renal cell carcinoma pathogenesis but n ot in progression or metastasis suppression.