INHIBITION OF POSTVITRECTOMY FIBRIN USING TROXERUTIN

Purpose: To evaluate the efficacy of intraocular infusion of troxeruti n in the inhibition of fibrin formation after vitrectomy in a rabbit m odel. Methods: Lensectomies and vitrectomies were performed in a maske d fashion on seven eyes treated with a 10-mM infusion of troxerutin an d on seven control eyes that received only a balanced salt solution in fusion. Masked grading of intraocular fibrin formation and intravitrea l hemorrhage was performed for 1 week.Results: On postoperative days 1 and 2, the control group exhibited a greater mean fibrin index (MFI) percentage than the troxerutin-treated group (day 1, 27.7% versus 19.5 % MFI; day 2, 14.5% versus 6.1% MFI, respectively). On postoperative d ay 3, both groups showed an MFI of 1.8%. On postoperative days 5 and 7 , both groups showed only minimal presence of fibrin. Neither of the t wo groups had an increased rate of intraocular hemorrhage. Conclusions : Infusion of 10 mM troxerutin resulted in a relative decrease in the amount of fibrin produced without an increased risk of intraocular hem orrhage in treated eyes compared with controls, but the difference was not statistically significant. Further studies may be warranted to ev aluate the optimal dose of troxerutin alone or a possible role for its use in conjunction with other drugs employing a different mechanism o f action in the prevention of fibrin formation.