CDI-RESTRICTED T-CELLS AND RESISTANCE TO POLYSACCHARIDE-ENCAPSULATED BACTERIA

Authors
FAIRHURST RM WANG CX SIELING PA MODLIN RL BRAUN J
Citation
Rm. Fairhurst et al., CDI-RESTRICTED T-CELLS AND RESISTANCE TO POLYSACCHARIDE-ENCAPSULATED BACTERIA, Immunology today, 19(6), 1998, pp. 257-259
Citations number
30
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
19
Issue
6
Year of publication
1998
Pages
257 - 259
Database
ISI
SICI code
0167-5699(1998)19:6<257:CTARTP>2.0.ZU;2-P
Abstract
CD1 has been distinguished from conventional antigen-presenting molecu les by its ability to present mycobacterial lipoglycans. Here, Rick Fa irhurst and colleagues postulate that the hydrophobic groove of CD1 bi nds palmitic acid, displaying diverse, covalently-attached carbohydrat es to T cells. Such T cells may constitute a previously unappreciated subset that helps B cells mount an antibody response to polysaccharide antigens.