PREVALENCE AND INCIDENCE OF CYTOMEGALOVIR US-INFECTION IN HIV-INFECTED SUBJECTS - THE FRENCH SEROCO COHORT

OBJECTIVES: To study prevalence of the cytomegalovirus (CMV) infection as well as incidence of the CMV seroconversions in HIV-infected subje cts enrolled in the French multicentric cohort SEROCO. METHOD: Prevale nce of CMV infection at inclusion in the cohort was estimated from 150 4 HIV-infected subjects. Incidence of the CMV seroconversion was estim ated from 184 subjects CMV seronegative at inclusion. Cox model was us ed to identify independent factors related to CMV seroconversion. RESU LTS: CMV prevalence was high (87.2%) mainly in homosexual men. The inc idence of the CMV seroconversions was also high (9,18/100 person-years ), particularly in homosexual men, in subjects declaring sexual interc ourse with occasional partner and in those declaring a sexually transm itted disease during the follow-up. CONCLUSION: The risk to develop se rious disease related to CMV in subjects with AIDS being particularly high when the CMV primary infection occurs during the course of the HI V infection, the prevention of CMV primary infections is thus a major element in the councelling of HIV-infected subjects. (C) 1998, Masson, Paris.