A. Steel et Ma. Hediger, THE MOLECULAR PHYSIOLOGY OF SODIUM-COUPLED AND PROTON-COUPLED SOLUTE TRANSPORTERS, News in physiological sciences, 13, 1998, pp. 123-131
The expression of cloned Na+- and H+-coupled solute transporters in Xe
nopus laevis oocytes has permitted detailed molecular and biophysical
analysis and illuminated unique mechanistic features. The identificati
on of missense mutations in inherited diseases and site-directed mutag
enesis studies have enhanced our understanding of their roles in physi
ological and pathological processes.