CUTANEOUS ULCERATION - AN UNUSUAL SIGN OF METHOTREXATE TOXICITY - FIRST REPORT IN A PATIENT WITHOUT PSORIASIS

OBJECTIVE: To describe a case of skin ulcer related to methotrexate to xicity. CASE SUMMARY: A 67-year-old white man with seronegative arthra lgia developed recurrent skin ulcer concurrent with 3-year treatment w ith methotrexate 5 mg daily. The skin ulcer resolved on discontinuatio n of methotrexate. DISCUSSION: To the best of our knowledge, this is t he first reported case of skin ulcer believed to be induced by methotr exate in a patient without psoriasis. CONCLUSIONS: Skin ulceration sho uld be added to the list of possible toxic adverse effects of methotre xate, not only in psoriatic patients but also in those without psorias is.