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STUDIES TOWARDS A TOTAL SYNTHESIS OF AMPHIDINOLIDE-B - STEREOCONTROLLED SYNTHESIS OF THE C-14-C26 POLYOL FRAGMENT

Authors

CID MB PATTENDEN G

Citation

Mb. Cid et G. Pattenden, STUDIES TOWARDS A TOTAL SYNTHESIS OF AMPHIDINOLIDE-B - STEREOCONTROLLED SYNTHESIS OF THE C-14-C26 POLYOL FRAGMENT, Synlett, (5), 1998, pp. 540

Citations number

Categorie Soggetti

Chemistry Inorganic & Nuclear

Journal title

Synlett → ACNP

ISSN journal

09365214

Issue

Year of publication

1998

Database

ISI

SICI code

0936-5214(1998):5<540:STATSO>2.0.ZU;2-5

Abstract

A practical synthesis of the C-14-C-26 polyol unit 2 in amphidinolides B-1 and B-2, 1 is described which involves elaboration of the chiral unsaturated aldehyde 4 and the chiral ketone 5, followed by crossed-al dolisation of 4 and 5 in the presence of LiHMDS at -78 degrees C, as k ey steps.