EFFECT OF POLAR GLYCOPEPTIDOLIPIDS FROM MYCOBACTERIUM-CHELONAE (GPLP-MC) ON PHAGOCYTOSIS AND SUPEROXIDE ANION PRODUCTION OF MACROPHAGES FROM MICE - INFLUENCE OF PHYSICAL-ACTIVITY

It is not clear how macrophages respond to exercise when the immune sy stem is previously activated. The aim of the present work was to deter mine the response of macrophages to exercise in already immunostimulat ed animals with polar glycopeptidolipids extracted from Mycobacterium chelonae (GPLp-Mc). Results showed an increased phagocytosis and O-2(- ) production in murine macrophages induced by the intraperitoneal admi nistration of 25 mg/kg body weight of GPLp-Mc. In addition exercise st imulated phagocytic activity and decreased the O-2(-) production of th ese cells. Unexpectedly, exercise did not potentiate the immunostimula tory effect of GPLp-Mc. However, we can conclude that the effect of ex ercise is not detrimental to immunostimulated animals.