Ni. Kononenko, DISSECTION OF A MODEL FOR MEMBRANE-POTENTIAL OSCILLATIONS IN BURSTINGNEURON OF SNAIL, HELIX-POMATIA, Comparative biochemistry and physiology. Part A, Physiology, 107(2), 1994, pp. 323-332
A slow-wave model for bursting activity based on the hyperpolarization
-activated outward current has been analysed by simulation of the well
-known experimental data. It is shown that the slow-wave model demonst
rates an increase of membrane input resistance during the development
of the depolarizing phase; responds adequately to stationary de- or hy
perpolarizing current; demonstrates a phenomenon of induced hyperpolar
ization and contingency. Change of definite model parameters selective
ly affects burst or interburst interval, and the period of slow-wave o
scillation. It is found that the investigated model, when using the sl
owest process (1.5 sec) can generate persistent oscillations with a pe
riod of more than 100 sec. Introduction of variable parameters in the
model simulates an initiation of slow-wave oscillation in Helix bursti
ng neuron evoked by stimulation of identified peptidergic interneuron.
The limitation of the presented model of slow-wave oscillation is dis
cussed.