EFFECTS OF INTRADUODENAL GLUCOSE-INFUSION ON GASTRIC MYOELECTRICAL ACTIVITY AND ANTROPYLORODUODENAL MOTILITY

Intraduodenal nutrient infusions cause an inhibition of antral motilit y and an increase in pyloric motility. The involvement of gastric myoe lectrical activity in this intestinogastric feedback was studied. Elec trogastrography and antropyloroduodenal manometry were performed in 10 healthy volunteers. The effects of 20-min infusions of 25% glucose (4 kcal/min) and saline were compared. Intraduodenal glucose infusions c aused a decrease in the power of the dominant frequency in the electro gastrogram (P = 0.028), but the frequency itself remained unchanged. T he total number of dysrhythmias increased (P = 0.035). An inhibition o f antral motor activity (P = 0.001), an increase in the number of isol ated pyloric pressure waves (P = 0.027), and an increase in basal pylo ric tone (P = 0.001) were simultaneously recorded. The change in power during glucose infusion correlated positively with the change in the antral motility index (r(s) = 0.50, P = 0.001). It is concluded that i nhibition of gastric myoelectrical activity is one of the mechanisms u nderlying an inhibition of motor activity in the gastric antrum.