Dl. Arnold et al., A MULTIGENERATION STUDY TO ASCERTAIN THE TOXICOLOGICAL EFFECTS OF GREAT-LAKES SALMON FED TO RATS - STUDY OVERVIEW AND DESIGN, Regulatory toxicology and pharmacology, 27(1), 1998, pp. 1-7
Fish from the Great Lakes can be contaminated with a plethora of indus
trial, agricultural, and environmental chemicals. These chemicals have
been associated with reproductive and other toxicological effects in
fish and fish-eating birds found in the Great Lakes basin. To obtain m
ore insight into this association, several laboratory studies have bee
n undertaken wherein fish have been incorporated into the experimental
diets to determine the effect of their ingestion upon the test animal
s. In addition, several human epidemiological studies have found corre
lations between Great Lakes fish consumption and effects in neonates w
hich have been attributed to polychlorinated biphenyls without any app
reciable consideration as to what synergistic or antagonistic effects
other chemicals or heavy metals may or may not have contributed to the
observed findings. Herein is presented the design of a two-generation
feeding-reproduction study that incorporated lyophilized chinook salm
on (Oncorhynchus tsawytscha) fillets into the diets of Sprague-Dawley
rats. The findings of this study will be presented in the sections whi
ch follow. (C) 1998 Academic Press.