Many patients with HIV/AIDS are now being treated with two or more dru
gs to reduce HIV viraemia and boost CD4 T-cell counts. Patients are us
ing these dregs earlier in the course of their disease and so GDPs are
likely to encounter them in practice. The drugs have dramatically alt
ered short term prognosis bet are patent and have potentially serious
drug interactions. Some of these drugs have interactions with drugs us
ed in the dental care setting and this paper sets out to summarise tho
se that are relevant in this area.