A CHEMOSELECTIVE, ACID-MEDIATED CONVERSION OF AMIDE ACETAL TO OXAZOLE- THE KEY STEP IN THE SYNTHESIS OF CARDIOVASCULAR DRUG, IFETROBAN SODIUM

Authors
SWAMINATHAN S SINGH AK LI WS VENIT JJ NATALIE KJ SIMPSON JH WEAVER RE SILVERBERG LJ
Citation
S. Swaminathan et al., A CHEMOSELECTIVE, ACID-MEDIATED CONVERSION OF AMIDE ACETAL TO OXAZOLE- THE KEY STEP IN THE SYNTHESIS OF CARDIOVASCULAR DRUG, IFETROBAN SODIUM, Tetrahedron letters, 39(27), 1998, pp. 4769-4772
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
27
Year of publication
1998
Pages
4769 - 4772
Database
ISI
SICI code
0040-4039(1998)39:27<4769:ACACOA>2.0.ZU;2-V
Abstract
The cyclization of acetal amide was carried out with trimethylsilyl tr ifluoromethanesulfonate, followed by elimination using sodium methoxid e to give 2,5-disubstituted oxazole, thus completing a new route to th e cardivascular drug ifetroban sodium. (C) 1998 Elsevier Science Ltd. All rights reserved.