A FACILE AND HIGHLY STEREOSELECTIVE APPROACH TO A POLYCYCLIC ISOINDOLINONE RING-SYSTEM VIA AN N-ACYLIMINIUM ION CYCLIZATION REACTION

Authors
ALLIN SM NORTHFIELD CJ PAGE MI SLAWIN AMZ
Citation
Sm. Allin et al., A FACILE AND HIGHLY STEREOSELECTIVE APPROACH TO A POLYCYCLIC ISOINDOLINONE RING-SYSTEM VIA AN N-ACYLIMINIUM ION CYCLIZATION REACTION, Tetrahedron letters, 39(27), 1998, pp. 4905-4908
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
27
Year of publication
1998
Pages
4905 - 4908
Database
ISI
SICI code
0040-4039(1998)39:27<4905:AFAHSA>2.0.ZU;2-N
Abstract
A highly diastereoselective synthesis of chiral ring-fused isoindolino ne products, the skeleton of which is common to many naturally occurri ng and biologically active compounds, is achieved in only two syntheti c steps from readily available precursors via an N-acyliminium ion cyc lization reaction of an isoindolinone substrate. (C) 1998 Elsevier Sci ence Ltd. All rights reserved.