SYNTHESIS OF COVALENT HEAD-TO-TAIL DIMERS OF VANCOMYCIN

Authors
STAROSKE T WILLIAMS DH
Citation
T. Staroske et Dh. Williams, SYNTHESIS OF COVALENT HEAD-TO-TAIL DIMERS OF VANCOMYCIN, Tetrahedron letters, 39(27), 1998, pp. 4917-4920
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
27
Year of publication
1998
Pages
4917 - 4920
Database
ISI
SICI code
0040-4039(1998)39:27<4917:SOCHDO>2.0.ZU;2-I
Abstract
The synthesis of covalent dimers of vancomycin which are linked from C -to N-terminus (head-to-tail linkage) is described. Such dimers have t he potential to exploit additional cooperative interactions when bindi ng to bacterial cell-wall precursors at a surface. (C) 1998 Elsevier S cience Ltd. All rights reserved.