SKELETAL-MUSCLE ABNORMALITIES IN PATIENTS WITH FIBROMYALGIA

Widespread muscle pain and tender points are the most common complaint s of fibromyalgia patients, and the underlying mechanisms responsible for these symptoms have been studied intensively during the past decad e. It has been suggested that fatigue and pain may lead to decreased l evels of physical activity in many patients. The resulting decondition ed state may itself contribute to muscle abnormalities. Associated sym ptoms such as disturbed sleep, anxiety, depression, or irritable bowel also may have a negative impact on muscle function and level of daily activities. The important interactions between the central nervous an d musculoskeletal systems may involve another element, the neuroendocr ine stress-response system. This review will consider both the current state of knowledge and also future studies which might be designed to answer more effectively the outstanding questions regarding the under lying pathogenesis of fibromyalgia.