We describe a patient with isolated voluntary facial paresis due to a
unilateral lacunar lesion in the contralateral mediodorsal middle base
of the pens. Transcranial magnetic stimulation confirmed the involvem
ent of supranuclear corticofacial tract fibers and sparing of the cort
icolingual and corticospinal connections. This observation demonstrate
s that the fibers conveying voluntary orofacial activation descend med
iodorsally at the level of the middle pens and that the fibers conveyi
ng emotional activation may be assumed to converge below this level.