CSF LEVELS OF CARNITINE IN CHILDREN WITH MENINGITIS, NEUROLOGIC DISORDERS, ACUTE GASTROENTERITIS, AND SEIZURE

Authors
SHINAWI M GRUENER N LERNER A
Citation
M. Shinawi et al., CSF LEVELS OF CARNITINE IN CHILDREN WITH MENINGITIS, NEUROLOGIC DISORDERS, ACUTE GASTROENTERITIS, AND SEIZURE, Neurology, 50(6), 1998, pp. 1869-1871
Citations number
9
Categorie Soggetti
Clinical Neurology
Journal title
Neurology → ACNP
ISSN journal
00283878
Volume
50
Issue
6
Year of publication
1998
Pages
1869 - 1871
Database
ISI
SICI code
0028-3878(1998)50:6<1869:CLOCIC>2.0.ZU;2-R
Abstract
Carnitine concentrations in CSF, serum, and urine in normal febrile ch ildren and children with meningitis, neurologic disorders, and dehydra tion were studied. Carnitine levels in CSF were 1/10 compared with ser um in normal febrile children. These levels increased two-to threefold in the pathologic conditions studied. Since damage to the blood-brain barrier occurs in these conditions, higher blood-brain barrier permea bility might explain CNS carnitine accumulation.