ALPHA-TOCOPHEROL IN CSF OF SUBJECTS TAKING HIGH-DOSE VITAMIN-E IN THEDATATOP STUDY

alpha-Tocopherol concentrations were determined in the CSF of patients with early untreated Parkinson's disease receiving 2,000 IU vitamin E orally per day. After treatment the concentrations increased signific antly (p < 0.001) by 76 +/- 10 (SE)%. The net increases in CSF alpha-t ocopherol concentrations after treatment showed a significant positive correlation with the number of days of vitamin E ingestion (p < 0.001 ). Thus, high-dose vitamin E treatment results in elevating CSF vitami n E levels and possibly brain vitamin E levels.