CONFIRMATION OF AN ASSOCIATION BETWEEN A POLYMORPHISM IN EXON-3 OF THE LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN GENE AND ALZHEIMERS-DISEASE

C766T, a polymorphism in exon 3 of the gene for the low-density lipopr otein receptor-related protein (LRP), was found to be associated with late-onset Alzheimer's disease (AD). We developed a PCR-restriction en zyme-based assay to analyze this allele in 234 AD patients and 103 con trols. We confirmed that the LRP C766T polymorphism was in disequilibr ium with AD-the C/C genotype was present in 76% of AD patients and 60% of controls (p < 0.01); however, the LRP polymorphism did not influen ce age at onset of AD.