THE CORRELATION OF STRUCTURE AND ACTIVITY OF PHENOLIC-COMPOUNDS TO DNA CLEAVAGE IN THE PRESENCE OF CUPRIC ION

Authors
HAYAKAWA F KIMURA T SOHMIYA H FUJITA M HOSHINO N ANDO T
Citation
F. Hayakawa et al., THE CORRELATION OF STRUCTURE AND ACTIVITY OF PHENOLIC-COMPOUNDS TO DNA CLEAVAGE IN THE PRESENCE OF CUPRIC ION, Nippon Nogei Kagakukaishi, 72(6), 1998, pp. 759-761
Citations number
7
Categorie Soggetti
Chemistry Applied","Food Science & Tenology",Agriculture,"Biothechnology & Applied Migrobiology","Nutrition & Dietetics
Journal title
Nippon Nogei Kagakukaishi → ACNP
ISSN journal
00021407
Volume
72
Issue
6
Year of publication
1998
Pages
759 - 761
Database
ISI
SICI code
0002-1407(1998)72:6<759:TCOSAA>2.0.ZU;2-7
Abstract
The effects of various phenolic compounds with cupric ion on DNA cleav age under aerobic conditions was examined using fluorometric analysis. Information on the relationship between their structure and DNA cleav age was obtained. The activity of compounds containing an OH group at the 3-position of the C-ring such as epigallocatechin and gallocatechi n, was much stronger than that of the corresponding ester. It was also found that the 2-hydroxy or 8-amino ethyl moiety at the para-position of pyrogallol or catechol is essential for potent activity.