AFFINITY OF ANTIOXIDATIVE POLYPHENOLS FOR LIPID BILAYERS EVALUATED WITH A LIPOSOME SYSTEM

We developed a method to measure the amounts of antioxidative polyphen ols and ubiquinones incorporated into the lipid bilayers of liposomes to estimate their affinities for cell membranes. Results were expresse d in terms of an ''affinity factor'', calculated by division of the am ount of compound incorporated by the amount added to the liposomal sol ution. The results reflected dose-dependence of the biological activit ies of the compound found in earlier in vitro experiments with mammali an and bacterial cells.