Background: There is an increasing need for improved microsurgical tec
hniques in the eye. Delivery of small quantities of chemicals or cells
into specific retinal locations, for example, cannot be achieved with
hand-held instruments. The present paper describes the design princip
les used in the development of a robotic ocular ultramicrosurgical sys
tem and the results from preliminary animal trials. Methods: We have d
eveloped a robotic ocular ultramicrosurgical system and a range of ins
truments for specific intraocular applications. Results: We have succe
ssfully used the system for intravascular (<70 mu m) drug delivery imp
lantation of microdrainage devices and the intraretinal manipulation o
f microelectrodes with minimal damage. Conclusion: A clinically usable
system using the same principles appears feasible.