Background: Data is reported from an ongoing trial considering whether
visual loss associated with mig raine is consistent with a selective
deficit in M- or P-cell functioning. Methods: The psychophysical tests
used include spatiotemporal contrast thresholds and luminance increme
nt thresholds for a spot drifting across a spatially or temporally mod
ulated background. A migraineur and 15 non-headache controls participa
ted in the present study. Measurements were made foveally and at 10 de
grees in the superior field. Static and flicker perimetry were conduct
ed. Result/Conclusion: Regionalized losses occurred for stimuli with m
oderate temporal frequencies (16 Hz), which is consistent with M-cell
dysfunction.