IMMUNOTACTOID GLOMERULOPATHY ASSOCIATED WITH IDIOPATHIC HYPEREOSINOPHILIC SYNDROME

A case of immunotactoid glomerulopathy in an 18-year-old man with an i diopathic hypereosinophilic syndrome is presented. The patient showed cervical lymphadenopathy, asymptomatic proteinuria of nephrotic range, and hematuria without any defined immunologic disease. Marked and pro longed hypereosinophilia was found in peripheral blood (eosinophil cou nt; 6,248/mm(3)) and bone marrow (eosinophil series; 32%). Diffuse and /or nodular eosinophilic infiltration was identified in multiple organ s such as kidney, stomach, liver, lymph node, and skin. Renal biopsy r evealed endocapillary proliferative features of typical immunotactoid glomerulopathy with IgG and C3 deposition and microtubular structures of variable size, 20-80 nm in diameter, mainly in the subendothelium. This study suggests that immunotactoid glomerulopathy may be a seconda ry immunologic manifestation of the tissue damage by eosinophils in th e idiopathic hypereosinophilic syndrome.