STUDY OF INTERACTIONS BETWEEN DRUGS AND METHANOL AT MICROWAVE FREQUENCY BY TIME-DOMAIN DIELECTRIC-SPECTROSCOPY

The complex permittivity of drugs in methanol at various temperatures and concentrations have been measured as a function of frequency betwe en 100 MHz to 10 GHz using (TDR) time domain reflectometry technique. Dielectric properties i.e. static dielectric constant, relaxation time were obtained from the complex permittivity spectra using non-linear least squares fit method. From the values of relaxation time, thermody namic parameters were determined. The Davidson-Cole model has been use d to find out the relaxation behaviour of the systems.