PARANEOPLASTIC DEMYELINATING NEUROPATHY, SUBACUTE SENSORY NEUROPATHY,AND ANTI-HU ANTIBODIES - CLINICOPATHOLOGICAL STUDY OF AN AUTOPSY CASE

A patient with anti-Hu antibodies, small-cell lung carcinoma, and auto psy-proven subacute sensory neuropathy had early slowing of motor and sensory conduction velocities. In the peripheral nerves, chronic demye linating and remyelinating lesions with axonal degeneration were assoc iated with an inflammatory reaction consisting of CD8+ T cells and CD6 8+ macrophages. On immunohistochemical testing, the patient's serum di d not react with normal nerve, suggesting that the Hu proteins were no t the target of the inflammatory reaction in the nerve. (C) 1998 John Wiley & Sons, Inc.