ABNORMALITIES OF CARDIAC REPOLARIZATION IN MULTIPLE-SCLEROSIS - RELATIONSHIP WITH A MODEL OF ALLERGIC ENCEPHALOMYELITIS IN RAT

Authors
DROUIN E NATAF S LANDE G LOUBOUTIN JP
Citation
E. Drouin et al., ABNORMALITIES OF CARDIAC REPOLARIZATION IN MULTIPLE-SCLEROSIS - RELATIONSHIP WITH A MODEL OF ALLERGIC ENCEPHALOMYELITIS IN RAT, Muscle & nerve, 21(7), 1998, pp. 940-942
Citations number
17
Categorie Soggetti
Neurosciences
Journal title
Muscle & nerve → ACNP
ISSN journal
0148639X
Volume
21
Issue
7
Year of publication
1998
Pages
940 - 942
Database
ISI
SICI code
0148-639X(1998)21:7<940:AOCRIM>2.0.ZU;2-5
Abstract
Ventricular repolarization was investigated for the first time in 48 m ultiple sclerosis (MS) patients using measurement of QTc interval on s tandard electrocardiographic recordings. The repolarization process wa s prolonged significantly in MS compared to control subjects (P = 0.00 01). This result was confirmed with an animal model of MS, i.e., the e xperimental allergic encephalomyelitis in rat. The contribution of pro longed QT to syncopal attack or sudden cardiac death in MS patients ne ed further investigation. (C) 1998 John Wiley & Sons, Inc.