PARANEOPLASTIC MOTOR-NEURON DISEASE WITH TYPE-1 PURKINJE-CELL ANTIBODIES

Autoimmune serological testing is a useful aid for identifying a paran eoplastic basis for sporadic motor neuron disease. A 67-year-old woman with ovarian carcinoma presented with progressive weakness. Neurologi cal examination was suggestive of motor neuron disease with signs of u pper motor neuron disorder. Electromyography revealed severe motor neu ronopathy of the upper extremities. Characteristic type 1 Purkinje cel l antibodies (anti-Yo antibody) was detected in the serum diluted at 1 :61,400. (C) 1998 John Wiley & Sons, Inc.