We describe an experimental surgical model in early rabbit embryo (12.
5 days of gestation), Twenty-one embryos were operated, of which 9 sur
vived the first postoperative week and 5 had normal further growth unt
il term, As far as we can ascertain, this is the first successful repo
rt of a surgical approach in early mammalian embryos. We think that th
is model may be useful for workers involved in the study of early cong
enital malformations.