EFFECTS OF ION TRANSFER AND MATRIX NATURE ON THE RESPONSE CHARACTERISTICS OF ION-SELECTIVE ELECTRODES REVERSIBLE TO IMIDAZOLE DERIVATIVES

Electrodes selective to some medicinal substances containing imidazole ring (Clotrimazol, Bifonazol, and Dibazol) were developed. The effect s of the nature of the polymeric matrix of the plasticized membrane an d the membrane solvent-plasticizer on the properties of these ion-sele ctive electrodes (ISEs) were studied. The transport of cations of medi cinal substances through membranes was studied by determining transfer ence numbers. The dependence of potentiometric selectivity coefficient s K-i/j(pot) On the transport properties of polymeric matrices and on the distribution coefficients of medicinal substances between aqueous and membrane solvent phases was found. Procedures for the rapid determ ination of Clotrimazol, Bifonazol, and Dibazol in tablets and ointment s by direct potentiometry are described.