A NEW SYNTHESIS OF 3,4,3-LI-1,2-HOPO (1,5 ,10,14-TETRA(1-HYDROXY-2-PYRIDONE-6 OYL)-1,5,10,14-TETRAAZATETRADECANE)

Authors
BAILLY T BURGADA R
Citation
T. Bailly et R. Burgada, A NEW SYNTHESIS OF 3,4,3-LI-1,2-HOPO (1,5 ,10,14-TETRA(1-HYDROXY-2-PYRIDONE-6 OYL)-1,5,10,14-TETRAAZATETRADECANE), COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE, 1(4), 1998, pp. 241-245
Citations number
15
Categorie Soggetti
Chemistry
Journal title
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE → ACNP
ISSN journal
13871609
Volume
1
Issue
4
Year of publication
1998
Pages
241 - 245
Database
ISI
SICI code
1387-1609(1998)1:4<241:ANSO3(>2.0.ZU;2-Y
Abstract
3,4,3 LI 1,2 HOPO is a very efficient ligand to remove actinides from the body after simulated contamination. Unfortunately the synthesis is not easy and the yield is small (15%). In this work we present a new facile synthesis with a good yield based on a protection-deprotection procedure of carboxyle and nitroxyde groups of the pyridone 1 and a ph ase transfer reaction for the peptide coupling step. (C) Academie des Sciences/Elsevier, Paris.