INCREASED RELEASE OF IAPP IN RESPONSE TO LONG-TERM HIGH-FAT INTAKE INMICE

In the present study, mice were fed high-fat diet or standard animal c how during 6 months. Animals fed high-fat diet showed a 4.5-fold incre ase in the fasting plasma IAPP levels compared to animals fed standard chow. No significant change in plasma insulin levels occurred between the groups. These differences in hormone response result in a change of the molar ratio between IAPP and insulin in the group fed high-fat diet. An increased IAPP to insulin molar ratio might be important in t he pathogenesis of islet amyloid in man.