REGULATION OF PHOSPHOLIPASE C-DELTA BY GTP-BINDING PROTEINS-RHOA AS AN INHIBITORY MODULATOR

Authors
HODSON EAM ASHLEY CC HUGHES AD LYMN JS
Citation
Eam. Hodson et al., REGULATION OF PHOSPHOLIPASE C-DELTA BY GTP-BINDING PROTEINS-RHOA AS AN INHIBITORY MODULATOR, Biochimica et biophysica acta. Molecular cell research, 1403(1), 1998, pp. 97-101
Citations number
41
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Molecular cell research → ACNP
ISSN journal
01674889
Volume
1403
Issue
1
Year of publication
1998
Pages
97 - 101
Database
ISI
SICI code
0167-4889(1998)1403:1<97:ROPCBG>2.0.ZU;2-J
Abstract
The regulation of Phospholipase C (PLC)delta activity remains obscure. These studies show that PLC delta(1) activity is significantly enhanc ed by both guanosine thiotriphosphate (GTP gamma S) and Clostridium bo tulinum exoenzyme C3 (C3) but not by aluminium fluoride. C3 ADP ribosy lated a 21-kDa protein in the PLC delta(1) preparation and Western blo tting identified rhoA in these samples. RhoA acts as an inhibitory mod ulator of PLC delta activity. (C) 1998 Elsevier Science B.V. All right s reserved.