SYNTHESIS OF SOME NEW 3-(CHLOROPHENYL)ISOCOUMARINS AND THEIR CONVERSION TO 3,4-DIHYDRO DERIVATIVES

Authors
RAMA NH IQBAL R RAUF A RAO MI ZAMANI KH RAZA AR
Citation
Nh. Rama et al., SYNTHESIS OF SOME NEW 3-(CHLOROPHENYL)ISOCOUMARINS AND THEIR CONVERSION TO 3,4-DIHYDRO DERIVATIVES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 37(4), 1998, pp. 338-341
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
37
Issue
4
Year of publication
1998
Pages
338 - 341
Database
ISI
SICI code
0376-4699(1998)37:4<338:SOSN3A>2.0.ZU;2-G
Abstract
Condensation of homophthalic acid 4 with chlorobenzoyl chlorides 5a-c yields 3-(chlorophenyl)isocoumarins 6a-c which on alkaline hydrolysis give the keto-acids 7a-c. (dl)-3-(Chlorophenyl)-3,4-dihydroisocoumarin s 10a-c have been obtained by the reduction of 7a-c to racemic hydroxy acids 9a-c followed by cyclodehydration using acetic anhydride.