PRACTICAL SYNTHESES OF ANTIVIRAL NUCLEOSIDES

Authors
IZAWA K SHIRAGAMI H
Citation
K. Izawa et H. Shiragami, PRACTICAL SYNTHESES OF ANTIVIRAL NUCLEOSIDES, Pure and applied chemistry, 70(2), 1998, pp. 313-318
Citations number
37
Categorie Soggetti
Chemistry
Journal title
Pure and applied chemistry → ACNP
ISSN journal
00334545
Volume
70
Issue
2
Year of publication
1998
Pages
313 - 318
Database
ISI
SICI code
0033-4545(1998)70:2<313:PSOAN>2.0.ZU;2-B
Abstract
Guanosine produced by fermentation is one of the nucleosides most read ily available on an industrial scale. We have recently developed sever al processes leading to known antiviral agents starting with guanosine . The processes involve enzymatic transglycosylation for stavudine (d4 T), chemical transpurination for acyclovir and ganciclovir, and novel alkylation for penciclovir and famciclovir.