Portfolio learning has not previously been reported for clinical under
graduate teaching. This open randomized study aimed to assess the effe
ct of portfolio learning in the teaching of oncology to medical studen
ts. The project aimed to provide the student with a holistic understan
ding of the impact of the disease and its treatment on the patient and
family, and the natural history of malignant disease, through long-te
rm personal experience of a cancer patient. All undergraduate medical
students entering Clinical Studies in October 1992 at the University o
f Wales College of Medicine were randomized to a study or control grou
p. Both groups continued with the standard curriculum. Each study-grou
p student followed a patient with cancer for 9 months, supported by bi
monthly small-group tutorials. Tutors were either general practitioner
s or hospital consultants, not necessarily oncologists; each was suppl
ied with a tutor's resource pack of key oncology review papers. Studen
ts recorded triggers to learning and key items in a personal learning
portfolio. Students' performances in clinical examinations and the con
tents of their portfolio were assessed. Final assessment was by hidden
questions in the objective structured clinical examination (OSCE) in
the final degree examination, when students in the study group showed
higher marks in factual knowledge of oncology, particularly amongst th
e weaker students (P = 0.01). Those submitting portfolios for formativ
e assessment had higher overall marks than those in the study group wh
o did not (P = 0.04), representing the more motivated students. The wh
ole study group showed a beneficial trend in their knowledge of oncolo
gy.