Random Matrix Theory provides an interesting tool for modelling a numb
er of phenomena where noises (fluctuations) play a prominent role. Var
ious applications range from the theory of mesoscopic systems in nucle
ar and atomic physics to biophysical models, like Hopfield-type models
of neural networks and protein folding. Random Matrix Theory is also
used to study dissipative systems with broken time-reversal invariance
providing a setup for analysis of dynamic processes in condensed, dis
ordered media. In the paper we use the Random Matrix Theory (RMT) with
in the formalism of Free Random Variables (alias Blue's functions), wh
ich allows to characterize spectral properties of non-Hermitean ''Hami
ltonians''. The relevance of using the Blue's function method is discu
ssed in connection with application of non-Hermitean operators in vari
ous problems of physical chemistry.