THE EFFECTS OF DANAZOL AFTER ENDOMETRIAL RESECTION - RESULTS OF A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND-STUDY

We report the results of a controlled, randomized, prospective, 'doubl e blind' evaluation of the effect of danazol treatment in 120 patients after hysteroscopic endometrial resection. After endometrial resectio n, the women were allocated to 1 of 3 groups: Group A - placebo; Group B - high-dose danazol (600 mg daily); Group C - low-dose danazol (200 mg daily) plus placebo tablets. Tablets were specifically manufacture d for the study, were identical in appearance, and were supplied in in dividual prepackaged boxes. The duration of treatment was 3 months and patients' compliance was noted. Amenorrhoea, dysmenorrhoea and premen strual tension symptoms were assessed for each,group by 1 or 2 indepen dent gynaecologists at follow-up intervals of 6 weeks, 3, 6 and 12 mon ths. A statistically-significant increased rate of amenorrhoea was fou nd in patients who received treatment with the higher-dose danazol (60 0 mg day) following endometrial resection. While not statistically sig nificant, the same trend was noted with the low-dose danazol. This res ult should influence our clinical management of women with menorrhagia , and the long-term results on the same cohort of patients are awaited with interest.