Bj. Nankivell et al., MAINTENANCE THERAPY WITH ORAL GANCICLOVIR AFTER TREATMENT OF CYTOMEGALOVIRUS-INFECTION, Clinical transplantation, 12(3), 1998, pp. 270-273
While oral ganciclovir (OGCV) has been used as primary prophylaxis in
patients at high risk for cytomegalovirus (CMV) infection after solid
organ transplantation, its value in secondary prophylaxis is unknown.
We have examined the use of OGCV as maintenance therapy following conf
irmed CMV infection on 16 occasions in 15 patients, in kidney (n = 4),
kidney-pancreas (n = 3) lung (n = 6) and heart-lung (n = 1) recipient
s. OGCV was used in two distinct clinical situations. One group (n = 7
) received OGCV as consolidation therapy (mean duration of 21 +/- 5 d)
following IV ganciclovir induction therapy (mean duration of 16 +/- 5
d) for acute CMV infection, and sustained remission was achieved in 6
/7 patients for a median follow-up of 300 d. In the second scenario, O
GCV suppressed clinical disease in all patients with relapsing CMV inf
ection (n = 9), with minimal or absent toxicity with a median follow-u
p of 152 d. OGCV reduced morbidity by allowing removal of central line
s used for long-term IV therapy in patients with poor peripheral acces
s. Hence, this study demonstrates the safe and effective use of OGCV a
s consolidation therapy after standard induction treatment with IV gan
ciclovir, and as long-term suppressive therapy in transplant recipient
s with recurrent CMV infection.