M. Ishibe et al., STIMULATION OF BONE-FORMATION IN-VIVO BY INSULIN-LIKE GROWTH-FACTOR-II IN RATS, Calcified tissue international, 63(1), 1998, pp. 36-38
Insulin-like growth factor-II (IGF-II) plays an important role in skel
etal remodeling, however, little is known about its effect on bone for
mation in vivo. In our study of the stimulation of bone formation in v
ivo by IGF-II we injected recombinant human IGF-II into the parietal b
ones of neonatal rats once a day for 12 days. The bone mineral density
measured by dual energy X-ray absorptiometry and the thickness of IGF
-II-injected parietal bones increased in a dose-dependent manner. The
layers of osteoblasts were observed along the IGF-II-injected side.