SYNTHESIS OF PYRAZOLOQUINOLINES AS GASTRIC H+ K+-ATPASE INHIBITORS/

Authors
KALAYANOV GD KANG SK CHEON HG LEE SG YUM EK KIM SS CHOI JK
Citation
Gd. Kalayanov et al., SYNTHESIS OF PYRAZOLOQUINOLINES AS GASTRIC H+ K+-ATPASE INHIBITORS/, Bulletin of the Korean Chemical Society, 19(6), 1998, pp. 667-671
Citations number
11
Categorie Soggetti
Chemistry
Journal title
Bulletin of the Korean Chemical Society → ACNP
ISSN journal
02532964
Volume
19
Issue
6
Year of publication
1998
Pages
667 - 671
Database
ISI
SICI code
0253-2964(1998)19:6<667:SOPAGH>2.0.ZU;2-9
Abstract
A series of l-aryl-1H-pyrazolo[4,3-c]quinolines and 2-aryl-2H-pyrazolo [4,3-c]quinolines are prepared by reacting 3-acyl-4-chloroquinolines i n ethanol or 3-acyl-4(1H)-quinolone in acetic acid with appropriate hy drazines as possible anti-ulcer agents. A regiospecific synthesis of l -aryl-1H-pyrazolo[4,3-c]quinolines is also achieved. The central pyrid ine ring could be easily reduced by catalytic hydrogenation.