CHEMICAL SYNTHESIS OF DISACCHARIDES WHICH ARE PARTIAL STRUCTURES OF THE GLYCOSAMINOGLYCAN HEPARAN-SULFATE

A specific tetradecasaccharide sequence (oligo-H, 1) of the proteoglyc an heparan sulfate has recently been identified as being responsible f or binding and activation of the basic fibroblast growth factor (bFGF) , a potent mitogen. We present here the first synthetic study towards partial structures of oligo-H and analogues. Our first target compound is the disaccharide 2, which corresponds to the dimeric repeat of the central decameric sequence of oligo-H.