RENAL TOLERANCE OF DIGOXIN-SPECIFIC FAB FRAGMENTS IN THE RAT

Renal markers were investigated over 96 h in male Sprague-Dawley rats after i.v. administration of 10.7 mg kg(-1) of digoxin-specific Fab fr agments (DSFab). The dose was calculated by an allometric equation as equivalent to a high clinical dose. DSFab both alone and pre-incubated with digoxin were tested. None of the markers (creatinine clearance, fractional excretion of sodium, urinary activities of gamma-glutamyl t ransferase and alkaline phosphatase) were significantly altered in tre ated rats compared to control rats. Thus no renal toxicity due to DSFa b alone or bound to digoxin was observed when administered at 10.7 mg kg(-1) in rats. (C) 1998 Elsevier Science Ireland Ltd. All rights rese rved.