B. Sozmen et al., EFFECT OF N-DICYCLOPROPYLMETHYL-AMINO-2-OXAZOLINE (S-3341) ON ANTIOXIDANT STATUS AND NITRIC-OXIDE IN HYPERTENSIVE PATIENTS, Current medical research and opinion, 14(2), 1998, pp. 89-96
Citations number
31
Categorie Soggetti
Medicine, General & Internal","Medicine, Research & Experimental
Defective endothelium-dependent vascular relaxation has been found in
animal models of hypertension and in hypertensive patients. An inbalan
ce due to reduced production of nitric oxide (NO) or increased product
ion of free radicals, mainly the superoxide anion, may facilitate the
development of an arterial functional spasm. Although it has been show
n that many antihypertensive drugs can normalise both tire antioxidant
activity and NO, the antioxidant effect of N-dicyclopropylmethyl-amin
o-2-oxazoline (S-3341), an alpha-adrenoreceptor agonist, has not been
investigated. In this study the investigated tire antioxidant and NO s
tatus in hypertensive patients and whether there was any effect of S-3
341 or? these parameters. Eleven patients with mild hypertension (mean
systolic blood pressure 159.5 +/- 2.5 mmHg) were administered S-3341
(1 mg/day) for 4 weeks. Plasma vitamin E, nitrite-nitrate and MDA leve
ls, and catalase activity, were measured both before and after treatme
nt with S-3341. There was significant reduction in both mean systolic
and diastolic blood pressure during the treatment. We found an increas
e irt catalase activity (p < 0.05), a decrease in malondialdehyde (MDA
) levels (p < 0.01) and an insignificant increase in vitamin E In els
in hypertensive patients following tire S-3341 treatment. We propose t
hat S-3341 may prevent oxidant stress in hypertensive patients by inhi
biting free-radical formation.