Sp. Khanapure et al., THE TOTAL SYNTHESIS OF TRITIATED AND DEUTERATED 5-PXO-ETE, A NOVEL INFLAMMATORY MEDIATOR, Journal of organic chemistry, 63(12), 1998, pp. 4098-4102
The total synthesis of 11,12,14,15-tetratritiated and deuterated 5-oxo
-ETE is accomplished using a novel bisacetylene precursor 14. The synt
heses of these labeled derivatives are necessary in order to investiga
te further the role and biochemistry of the novel inflammatory mediato
r and eosinophilic chemotactic agent 5-oxo-ETE.