SYNTHESIS AND BIOLOGICAL EVALUATION OF 14-ALKOXYMORPHINANS - PART 15 - NOVEL DELTA-OPIOID RECEPTOR ANTAGONISTS WITH HIGH-AFFINITY AND SELECTIVITY IN THE 14-ALKOXY-SUBSTITUTED INDOLOMORPHINAN SERIES

Authors
SCHMIDHAMMER H KRASSNIG R GREINER E SCHUTZ J WHITE A BERZETEIGURSKE IP
Citation
H. Schmidhammer et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF 14-ALKOXYMORPHINANS - PART 15 - NOVEL DELTA-OPIOID RECEPTOR ANTAGONISTS WITH HIGH-AFFINITY AND SELECTIVITY IN THE 14-ALKOXY-SUBSTITUTED INDOLOMORPHINAN SERIES, Helvetica Chimica Acta, 81(6), 1998, pp. 1064-1069
Citations number
26
Categorie Soggetti
Chemistry
Journal title
Helvetica Chimica Acta → ACNP
ISSN journal
0018019X
Volume
81
Issue
6
Year of publication
1998
Pages
1064 - 1069
Database
ISI
SICI code
0018-019X(1998)81:6<1064:SABEO1>2.0.ZU;2-Z
Abstract
The indolomorphinans 4-7 were prepared from their corresponding morphi nan-6-one derivatives 8-11 via Fischer indole synthesis. Compounds 4 a nd 5 exhibited higher antagonist potency at delta opioid receptors in the mouse vas deferens preparation than the reference drug HS 378 (2), while compounds 6 and 7 were less potent.