SYNTHESIS OF VITAMIN-B12 DERIVATIVES WITH PERIPHERAL TRIS(OXYETHYLENE) CHAINS

Authors
PFAMMATTER MJ DARBRE T KEESE R
Citation
Mj. Pfammatter et al., SYNTHESIS OF VITAMIN-B12 DERIVATIVES WITH PERIPHERAL TRIS(OXYETHYLENE) CHAINS, Helvetica Chimica Acta, 81(6), 1998, pp. 1105-1116
Citations number
23
Categorie Soggetti
Chemistry
Journal title
Helvetica Chimica Acta → ACNP
ISSN journal
0018019X
Volume
81
Issue
6
Year of publication
1998
Pages
1105 - 1116
Database
ISI
SICI code
0018-019X(1998)81:6<1105:SOVDWP>2.0.ZU;2-N
Abstract
The new derivatives 7a-c, of vitamin B-12, with a peripheral tris(oxye thylene) chain linked to the corrin ring by an amide or ester group, a re prepared, and their ligand-exchange reactions are investigated. Upo n reduction of the aqua-cyano complexes 8a-c with NaBH4, cleavage of t he 'outer' ester and amide group is observed.