A NOVEL TRANSFORMING-GROWTH-FACTOR BETA(2) ANTISENSE TRANSCRIPT IN MAMMALIAN LUNG

Authors
COKER RK LAURENT GJ DABBAGH K DAWSON J MCANULTY RJ
Citation
Rk. Coker et al., A NOVEL TRANSFORMING-GROWTH-FACTOR BETA(2) ANTISENSE TRANSCRIPT IN MAMMALIAN LUNG, Biochemical journal, 332, 1998, pp. 297-301
Citations number
25
Categorie Soggetti
Biology
Journal title
Biochemical journal → ACNP
ISSN journal
02646021
Volume
332
Year of publication
1998
Part
2
Pages
297 - 301
Database
ISI
SICI code
0264-6021(1998)332:<297:ANTBAT>2.0.ZU;2-V
Abstract
Transforming growth factor (TGF) beta(2) gene expression was examined in murine, rat and human lung by in situ hybridization with riboprobes . Hybridization signal was observed in a variety of cells with the sen se probe, and Northern-blot analysis with this probe demonstrated the presence of a novel 3.5 kb transcript. This first report suggesting th e existance of a natural TGF beta(2) antisense transcript raises the p ossibility that such a transcript may play a role in regulating TGF be ta(2) production.