FLOW-INJECTION SPECTROPHOTOMETRIC DETERMINATION OF DICLOFENAC SODIUM IN PHARMACEUTICALS AND URINE SAMPLES

Authors
GARCIA MS ALBERO MI SANCHEZPEDRENO C MOLINA J
Citation
Ms. Garcia et al., FLOW-INJECTION SPECTROPHOTOMETRIC DETERMINATION OF DICLOFENAC SODIUM IN PHARMACEUTICALS AND URINE SAMPLES, Journal of pharmaceutical and biomedical analysis, 17(2), 1998, pp. 267-273
Citations number
31
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Analytical
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
17
Issue
2
Year of publication
1998
Pages
267 - 273
Database
ISI
SICI code
0731-7085(1998)17:2<267:FSDODS>2.0.ZU;2-E
Abstract
A sensitive and fast flow-injection spectrophotometric method for the determination of diclofenac sodium based on the formation of coloured compound with Ce(IV)-3-methyl-2-benzothiazolinone hydrazone hydrochlor ide (MBTH) in H2SO4 3 x 10(-2) M medium is proposed. Using the peak he ight as a quantitative parameter diclofenac was determined at 580 nm o ver the range 0.20-8.0 mu g ml(-1). The proposed method was successful ly applied to the determination of diclofenac in pharmaceuticals and u rine samples. (C) 1998 Elsevier Science B.V. All rights reserved.